Work

Polycomb Repressor Complex 2 in Genomic Instability and Cancer

Year: 2017

Type: review

Abstract: Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms18081657

Authors: Zoe Veneti, Kalliopi Gkouskou, Aristides Eliopoulos

Institutions: University of Crete, Technological Educational Institute of Athens, Foundation for Research and Technology Hellas

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499