Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development
Year: 2017
Type: article
Abstract: ) causes extremely poor ability in spatial memory formation. Knockdown of TERT in the dentate gyrus of adult hippocampus impairs spatial memory processes, while overexpression facilitates it. We find that TERT plays a critical role in neural development including dendritic development and neuritogenesis of hippocampal newborn neurons. A monosynaptic pseudotyped rabies virus retrograde tracing method shows that TERT is required for neural circuit integration of hippocampal newborn neurons. Interestingly, TERT regulated neural development and spatial memory formation in a reverse transcription activity-independent manner. Using X-ray irradiation, we find that hippocampal newborn neurons mediate the modulation of spatial memory processes by TERT. These observations reveal an important function of TERT through a non-canonical pathway and encourage the development of a TERT-based strategy to treat neurological disease-associated memory impairment.
Source: Stem Cell Reports
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,190
Funders: American Federation for Aging Research, Whitehall Foundation, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, National Key Research and Development Program of China, National Institute on Alcohol Abuse and Alcoholism
OpenAlex ID: W2739718754