Work

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2 -deficient mice

Year: 2017

Type: article

Abstract: knockout mice. Together, these results suggest that real-time modulation of E:I balance in the mouse prefrontal cortex can rescue social behavior deficits reminiscent of autism phenotypes.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aah6733

Authors: Aslihan Selimbeyoglu, Christina K. Kim, Masatoshi Inoue, Soo Yeun Lee, Alice S. O. Hong, Isaac Kauvar, Charu Ramakrishnan, Lief E. Fenno, Thomas J. Davidson, Matthew Wright, Karl Deisseroth

Institutions: Stanford University, Stanford Medicine, Howard Hughes Medical Institute

Language: English

Topic: Genetics and Neurodevelopmental Disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute on Drug Abuse

Awards: Top-down regulation of compulsive reward-seeking behavior by medial prefrontal cortex, G2329388324

OpenAlex ID: W2740920123

FWCI: 16.53

Cites: 47

Cited by: 341

Related to: 10