Electrochemical Oxidation of Loop Diuretic Furosemide at Gold Electrode and its Analytical Applications
Year: 2009
Type: article
Abstract: Electrochemical oxidation of loop diuretic furosemide at gold electrode was investigated by cyclic, linear sweep and differential pulse voltammetric (DPV) techniques. The electrochemical studies were carried out in methanol: water (10:90) in 4.8 pH with 0.04 mol/l Britton-Robinson buffer as supporting electrolyte at 25±0.20 C. The effects of scan rate, concentration, surfactant and temperature were evaluated. The electrochemical process was observed to be adsorption controlled, irreversible and involving two-electron oxidation. Effects of anodic peak potential (Epa), anodic peak current (ipa) and heterogeneous rate constant (k0) have been discussed. A DPV method with good precision and accuracy was developed for the determination of furosemide in pharmaceutical formulations. The linear response was obtained in the range of 6.0 x 10-6 to 8.0 x 10-4 M with detection limit of 4.12 x 10-8 M. The proposed method was successfully applied to the individual tablet dosage form.
Institutions: Karnatak University, Indian Institute of Technology Delhi
Language: English
Subfield: Electrochemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,670
OpenAlex ID: W2741276136