Work

The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis

Year: 2017

Type: review

Abstract: // Peng Gao 1, * , Na Niu 2, * , Tianshu Wei 1 , Hideto Tozawa 3 , Xiaocui Chen 1 , Caiqing Zhang 4 , Jiandong Zhang 5 , Youichiro Wada 3 , Carolyn M. Kapron 6 and Ju Liu 1 1 Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China 2 Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China 3 The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan 4 Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China 5 Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China 6 Department of Biology, Trent University, Peterborough, Ontario, Canada * These authors contributed equally to this work Correspondence to: Ju Liu, email: [email protected] Keywords: STAT3, tumor angiogenesis, transcriptional regulation, endothelial cells Received: June 28, 2017 Accepted: July 26, 2017 Published: August 04, 2017 ABSTRACT Angiogenesis is the development of new blood vessels, which is required for tumor growth and metastasis. Signal transducer and activator of transcription factor 3 (STAT3) is a transcription factor that regulates a variety of cellular events including proliferation, differentiation and apoptosis. Previous studies revealed that activation of STAT3 promotes tumor angiogenesis. In this review, we described the activities of STAT3 signaling in different cell types involved in angiogenesis. Particularly, we elucidated the molecular mechanisms of STAT3-mediated gene regulation in angiogenic endothelial cells in response to external stimulations such as hypoxia and inflammation. The potential for STAT3 as a therapeutic target was also discussed. Overall, this review provides mechanistic insights for the roles of STAT3 signaling in tumor angiogenesis.

Source: Oncotarget

DOI: 10.18632/oncotarget.19932