Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory
Year: 2017
Type: article
Abstract: . The acquired expression state behaved as an "epiallele," being inherited for multiple generations before fully resetting. Derepression was not restricted to the transgene but was caused by a global reduction in heterochromatin-associated histone modifications due to the impaired retention of modified histones on DNA during replication in the early embryo. Impaired DNA replication during development can therefore globally derepress chromatin, creating new intergenerationally inherited epigenetic expression states.
Source: Science Advances
Institutions: Universitat Pompeu Fabra, European Molecular Biology Laboratory, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Institute of Predictive and Personalized Medicine of Cancer, Josep Carreras Leukaemia Research Institute, Institució Catalana de Recerca i Estudis Avançats
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: G4678326537, G7666733349, G8804548721
OpenAlex ID: W2747710600