Work

Alkyne–azide cycloaddition analogues of dehydrozingerone as potential anti-prostate cancer inhibitors via the PI3K/Akt/NF-kB pathway

Year: 2017

Type: article

Abstract: Alkyne–azide cycloaddition derivatives of DHZ ( 1 ) were synthesized and screened for cytotoxic potential in which the derivatives, 3 , 6 , 7 , 8 , 9 and 15 displayed most potent with IC 50 value ranging from 1.8–3.0 μM.

Source: MedChemComm

DOI: 10.1039/c7md00267j

Authors: Chetan Kumar, Reyaz Ur Rasool, Zainab Iqra, Yedukondalu Nalli, Prabhu Dutt, Naresh K. Satti, Neha Sharma, Sumit G. Gandhi, Anindya Goswami, Asif Ali

Institutions: Indian Institute of Integrative Medicine, Council of Scientific and Industrial Research, Academy of Scientific and Innovative Research

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministry of AYUSH, Government of India, Ministry of Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy

Award: G7166087668

OpenAlex ID: W2765246760

FWCI: 1.166

Cites: 31

Cited by: 23

Related to: 10