Work

A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia

Year: 2017

Type: article

Abstract: Key Points IFPs can convert signals from inhibitory ligands into activating signals. Costimulation was most effectively achieved by engineering the IFP to promote the ability to localize in the immunological synapse.

Source: Blood

DOI: 10.1182/blood-2017-04-777052

Authors: Shannon K. Oda, Andrew W. Daman, Nicolas M. Garcia, Felecia Wagener, Thomas M. Schmitt, Xiaoxia Tan, Aude G. Chapuis, Philip D. Greenberg

Institutions: Fred Hutch Cancer Center, University of Washington

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: G1470381490, MECHANISMS OF MURINE TUMOR ERADICATION BY IMMUNOTHERAPY, G7722729414, G87770821

OpenAlex ID: W2766547496

FWCI: 1.989

Cites: 52

Cited by: 62

Related to: 10