Stability Indicating High Performance Liquid Chromatographic Assay for the Determination of Sildenafil Tartrate
Year: 2017
Type: article
Abstract: A simple, fast, accurate and specific reverse phase high pressure liquid chromatographic (HPLC) method has been developed for simultaneous determination of Sildenafil base and its impurities in the Sildenafil Tartrate (API). The method was developed by reversed phase chromatography equipped with C18 (100 × 4.6 nm × 5.0 nm) column using mobile phase of (0.1%) formic acid and methanol (30: 70 ratio) with a flow rate of 0.5 ml/min with ultraviolet detector configured at 290nm. The method was validated as per ICH guidelines.
Authors: O.S.S. Chandana, R. Ravichandra Babu
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2766827434