Exome-wide association study of plasma lipids in >300,000 individuals
Year: 2017
Type: article
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.3977
Authors: Charge Diabetes Working Group, Dajiang J Liu, VA Million Veteran Program, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David C M Liewald, Li An Lin, Allan Linneberg, Ruth J F Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas G D Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin N A Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter W F Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Joanna M M Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
Institutions: Pennsylvania State University, Broad Institute, Boston University, Harvard University, Harvard Stem Cell Institute, University of Cambridge, National Institute for Health and Care Research, University of Pennsylvania, Centre for Human Genetics, University of Oxford, Center for Non-Communicable Diseases, Massachusetts General Hospital, International Centre for Diarrhoeal Disease Research, Imperial College London, Inserm, Institut Pasteur de Lille, Centre Hospitalier Universitaire de Lille, Approches épidémiologiques et moléculaires intégratives visant à améliorer la compréhension des maladies chroniques liées au vieillissement, Université de Strasbourg, VA Palo Alto Health Care System, Stanford Medicine, Stanford University, University of Wisconsin–Milwaukee, Icahn School of Medicine at Mount Sinai, Baylor College of Medicine, Copenhagen University Hospital, Rigshospitalet, University of Copenhagen, University of Washington, University of Michigan, The University of Texas Health Science Center at Houston, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Southern Denmark, Vejle Sygehus, Lillebaelt Hospital, Queen Mary University of London, William Harvey Research Institute, Institute of Genetic and Biomedical Research, National Research Council, NIHR Barts Cardiovascular Biomedical Research Unit, Imperial College Healthcare NHS Trust, Ealing Hospital NHS Trust, Brigham and Women's Hospital, Michigan Medicine, University of California, Los Angeles, Harbor–UCLA Medical Center, Framingham Heart Study, University of Dundee, Ninewells Hospital, University of Sassari, Philadelphia VA Medical Center, University of Edinburgh, Harokopio University of Athens, Vanderbilt University Medical Center, University of Glasgow, Montreal Heart Institute, Université de Montréal, Oulu University Hospital, University of Oulu, Icelandic Heart Association, University of Tartu, Washington University in St. Louis, University of Insubria, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, Lund University, Umeå University, University of Exeter, Spanish National Centre for Cardiovascular Research, Peking University Third Hospital, National Institutes of Health, National Heart, Lung, and Blood Institute, Helmholtz Munich, German Center for Diabetes Research, Cedars-Sinai Medical Center, University of Iceland, National Institute on Aging, Institute of Genetics and Cancer, MRC Human Genetics Unit, Boston Children's Hospital, Norwegian University of Science and Technology, St Olav's University Hospital, Peking University First Hospital, Frederiksberg Hospital, Leiden University Medical Center, Netherlands Heart Institute, Gentofte Hospital, NIHR Oxford Biomedical Research Centre, Oxford Centre for Diabetes, Endocrinology and Metabolism, Queen's University Belfast, VA Boston Healthcare System, University of Helsinki, Helsinki University Hospital, Finnish Institute for Health and Welfare, Minerva Foundation, Hammersmith Hospital, Fred Hutch Cancer Center, University of Eastern Finland, Kuopio University Hospital, MRC Epidemiology Unit, Aarhus University, Glostrup Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, Karolinska Institutet, Pfizer (Sweden), University of Virginia, University of Leicester, Glenfield Hospital, NIHR Leicester Biomedical Research Centre, University of Liverpool, German Centre for Cardiovascular Research, Ludwig-Maximilians-Universität München, Madrid Institute for Advanced Studies, Tufts University, Jean Mayer Human Nutrition Research Center on Aging, IMDEA Food, Merck & Co., Inc., Rahway, NJ, USA (United States), Institute for Molecular Medicine Finland, University of Split, Kaiser Permanente Washington Health Research Institute, National University of Singapore, Amsterdam UMC Location University of Amsterdam, University of Amsterdam, King's College London, Wellcome Sanger Institute, Alzheimer Scotland, Kanazawa University, Columbia University, Universität für Weiterbildung Krems, King Abdulaziz University, Dasman Diabetes Institute, Indiana University Indianapolis, Indiana University School of Medicine, Indiana University, University of Mississippi Medical Center, Emory Clinic, Atlanta VA Medical Center, Yale University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Eli Lilly and Company, AstraZeneca, Sanofi, Massachusetts General Hospital, Alnylam Pharmaceuticals, Vanderbilt University, University of Pennsylvania, Donovan Family Foundation, European Hematology Association, Regeneron Pharmaceuticals, Wellcome Trust, Vanderbilt University Medical Center, Broad Institute, Sarnoff Cardiovascular Research Foundation, Quest Diagnostics, Steno Diabetes Center Copenhagen, National Institute for Health and Care Research, British Heart Foundation, Bayer HealthCare, Gentofte Hospital, Lundbeckfonden, Japanese Circulation Society, Rigshospitalet, Faculty of Health and Medical Sciences, University of Western Australia, Novo Nordisk Fonden, National Institutes of Health, Directorate for Biological Sciences, Perelman School of Medicine, University of Pennsylvania, Medical Research Council, NIHR Exeter Clinical Research Facility, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Human Genome Research Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, FP7 Ideas: European Research Council
Awards: G1031160829, G1047385862, FHCRC High-Performance Computing Cluster, Aetiology of type 2 diabetes and related metabolic disorders, Genetic Variants Associated with HDL and LDL Cholesterol, and Triglyceride Levels, G137869731, G1422855837, G1449261147, The causes of hyperglycaemia in the face of rising obesity, G1576437321, NIHR Senior Investigator Award, G186817731, G2107972360, G2155906325, G2173156417, G2227959769, Genetic Studies of The Impact of Hematologic Traits On Cardiovascular Disease, G232264632, G2676572314, Genetic Association Meta-Analyses of Smoking and Drinking for the Sequencing Age, G2892497062, G297113894, G2988741787, G2993681707, G301048564, G3161388866, Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC Supercomputer, G343705321, G353496842, G362946481, G3761937116, G3803372573, G3812975344, G3824783914, G385201875, G3935709649, G4203797140, G4211044638, G4429312988, G4959866566, G50080621, G501472786, G5067462658, NIHR Senior Investigator Award, Discovering lipoprotein lipase pathway variants that protect against CHD, G5787426001, NIHR Senior Investigator Award, G5915125647, Rare Sequence Variation and Diabetes Quantitative Traits, G6105553142, G6146974483, G6173713322, G6433152044, G6635015925, G6654704239, G6800011207, G6957823285, Identification and functional impact of NAFLD associated genetic variants, The BHF Chair of Epidemiology and Medicine, G7358202551, Harvard Clinical and Translational Science Center, Large-scale integrative studies of risk factors in coronary heart disease: from discovery to application (renewal). (Joint funding with MRC), Using genetics to explore the pathophysiology of cerebral small vessel disease. 15, G775909998, G7953181477, G812891927, G814381192, G843141311, G8437048056, RENEWAL: Systematic approaches to the evaluation of emerging coronary risk markers. Large-scale epidemiological analyses of existing data and stored biological samples, NIHR Senior Investigator Award, Genomics of coronary arthery disease. ,, NIHR Senior Investigator Award, G9000020190, G9000040690, G9000057048, G9000098084, G9000189813, G9000242903, G9000248640, NYR-Diabetes Research Center (NYR-DRC), G937306755
OpenAlex ID: W2767038995