Work

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Year: 2017

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2017.11.024

Authors: Anthony B. Pinkerton, Eduard Sergienko, Yalda Bravo, Russell Dahl, Chen-Ting Ma, Qing Sun, Michael R. Jackson, Nicholas D.P. Cosford, José Luis Millán

Institutions: Sanford Burnham Prebys Medical Discovery Institute, National Cancer Institute

Language: English

Topic: Alkaline Phosphatase Research Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Human Genome Research Institute, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research

Awards: Mechanisms of initiation of skeletal mineralization, Molecular Pathogenesis and Treatment of Hypophosphatasia, Sanford-Burnham Center for Chemical Genomics, Lead Optimization of Novel Inhibitors of Tissue Non-specific Alkaline Phosphatase, Cancer Center Support Grant (CCSG)

OpenAlex ID: W2767386149

FWCI: 3.692

Cites: 17

Cited by: 46

Related to: 10