New melanocortin-like peptide of E. coli can suppress inflammation via the mammalian melanocortin-1 receptor (MC1R): possible endocrine-like function for microbes of the gut
Year: 2017
Type: article
Abstract: elongation factor-G (EF-G) and has interesting similarities to two prominent mammalian melanocortin hormones, alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH). Note that MECO-1 lacks HFRW, the common pharmacophore of the known mammalian melanocortin peptides. MECO-1 and the two hormones were equally effective in severely blunting release of cytokines (HMGB1 and TNF) from macrophage-like cells in response to (i) endotoxin (lipopolysaccharide) or (ii) pro-inflammatory cytokine HMGB-1. The in vitro anti-inflammatoty effects of MECO-1 and of alpha-MSH were abrogated by (i) antibody against melanocortin-1 receptor (MC1R) and by (ii) agouti, an endogenous inverse agonist of MC1R. In vivo MECO-1 was even more potent than alpha-MSH in rescuing mice from death due to (i) lethal doses of LPS endotoxin or (ii) cecal ligation and puncture, models of sterile and infectious sepsis, respectively.
Source: npj Biofilms and Microbiomes
Authors: Xiaoling Qiang, Anthony S. Liotta, Joseph Shiloach, J. C. Gutierrez, Haichao Wang, Mahendar Ochani, Kanta Ochani, Huan Yang, Aviva Rabin, Derek LeRoith, Maxine A. Lesniak, Markus Böhm, Christian Maaser, Klaus Kannengiesser, Mark Donowitz, Shervin Rabizadeh, Christopher J. Czura, Kevin J. Tracey, Mark Westlake, Aida Zarfeshani, Syed F. Mehdi, Ann Danoff, Xueliang Ge, Suparna Sanyal, Gary J. Schwartz, Jesse Roth
Institutions: Northwell Health, Feinstein Institute for Medical Research, Hofstra University, National Institutes of Health, Icahn School of Medicine at Mount Sinai, University of Münster, Johns Hopkins University, Cedars-Sinai Medical Center, University of Pennsylvania, Uppsala University, Albert Einstein College of Medicine
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,290
Awards: HOPKINS DIGESTIVE DISEASE BASIC RESEARCH DEVELOPMENT CENTER, G1296064655, G2586779191, PHYSIOLOGY AND CLONING OF B FRAGILIS ENTEROTOXIN, Transporters and Trafficking in Polarized Epithelial Cells, NHE3 Regulation and Signaling Complexes, Diarrheal Disease: Physiologic Approach to Treatment, Brainstem nutrient sensing in the integrative control of food intake, New York Obesity Research Center, NYR-Diabetes Research Center (NYR-DRC)
OpenAlex ID: W2767540237