Work

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

Year: 2017

Type: article

Abstract: Tumor-derived lactate induced naïve T cell apoptosis via suppressing FIP200 expression and autophagy formation, resulting in mitochondria activation and imbalance of Bcl-2 family members in T cells.

Source: Science Immunology

DOI: 10.1126/sciimmunol.aan4631

Authors: Houjun Xia, Wei Wang, Joel Crespo, Ilona Kryczek, Wei Li, Shuang Wei, Zhaoqun Bian, Tomasz Maj, Mingxiao He, Rebecca J. Liu, Youwen He, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Weiping Zou

Institutions: University of Michigan, Michigan Medicine, Peking University, University of Cincinnati Medical Center, Duke University, Henry Ford Health, U-M Rogel Cancer Center

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Awards: Novel immunosupressive macrophages in human ovarian tumor, G1404790370, G1786018887, G2117675313, G2454747299, G354465546, G378389786, G6612995435, G6879136734, Naive T cells in Cancer Immune Evasion and Immunotherapy, G9000031927, G9000217340

OpenAlex ID: W2769614741

FWCI: 6.122

Cites: 54

Cited by: 150

Related to: 10