Work

Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

Year: 2017

Type: article

Abstract: A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.

Source: Chemical Communications

DOI: 10.1039/c7cc08039e

Authors: Chengli Mou, Jichang Wu, Zhijian Huang, Jun Sun, Zhichao Jin, Yonggui Robin Chi

Institutions: Guizhou University, Nanyang Technological University

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze