Fabrication of Porous Titanium-Polyglycolide-Calcium Carbonate Composite as Bone Replacement Material
Year: 2017
Type: article
Abstract: Porous materials show low Young’s moduli and excellent bonding to living bone. However, the strength of such materials is often insufficient in the initial stage of implantation. Thus, the objective of this study was to increase strength and Young’s modulus of porous titanium by filling the pores with a biodegradable mixture of polyglycolide (PGA) and calcium carbonate (CaCO3). The mixture was introduced into porous Ti (porosity: 60%) using a heat injection technique. When the pores were filled with PGA-CaCO3, compressive strength and Young’s moduli were drastically increased and influenced by the content of CaCO3. In an animal test, unfavourable autopsy findings could not be confirmed in rats and no bone was observed in the pores of the Ti-PGA composite. Decomposition of PGA lowered the surrounding pH, it was found to inhibit bone formation in the pores. Addition of CaCO3 to PGA could suppress the decrease in pH.
Source: KOBUNSHI RONBUNSHU
Authors: Masato UEDA, Masahiko IKEDA, Kenji DOI, Shigeo MORI, Hisashi KITAGAKI, Shuntaro TERAUCHI, Azusa SEKI
Institution: Kansai University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2769979601