Evolutionary analysis of mumps viruses of genotype F collected in mainland China in 2001–2015
Year: 2017
Type: article
Abstract: Mumps incidence in mainland China remains at a high level. Genotype F has been the predominant genotype of mumps virus (MuV) in the last 20 years in mainland China. To better understand the genetic characteristics of MuV in China, the sequences of the Small Hydrophobic (SH), Hemagglutinin-Neuraminidase (HN) and Fusion (F) genes of MuVs of genotype F collected during 2001–2015 were determined. The evolutionary rates of the HN and F genes were similar (0.5 × 10−3 substitutions/site/year) whereas the SH gene evolutionary rate was three times faster. The most recent common ancestor of genotype F was traced back to 1980. Four lineages were identified within HN and F MuV sequences. A phylogeographic analysis indicated that the genotype F viruses originally spread from the Liaoning and Shandong provinces followed by a spread to the South and East of China. This study provides important genetic baseline data for the development of prevention and control measures of mumps.
Source: Scientific Reports
Authors: Aili Cui, Pierre Rivailler, Zhen Zhu, Xiuying Deng, Ying Hu, Yan Wang, Fangcai Li, Zhaodan Sun, Jilan He, Yuan Si, Xiaoling Tian, Shujie Zhou, Yake Lei, Huanying Zheng, Paul A. Rota, Wenbo Xu
Institutions: Chinese Center For Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Centers for Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Hunan Provincial Center for Disease Control and Prevention, Sichuan Center for Disease Control and Prevention, Inner Mongolia Comprehensive Disease Prevention and Control Center, Anhui Provincial Center for Disease Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Anhui University of Science and Technology
Language: English
Topic: Virology and Viral Diseases
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2772049484