Work

A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

Year: 2017

Type: article

Abstract: A microglial-like cellular model can be used to identify functional consequences of genetic variants associated with neurodegenerative disease.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aai7635

Authors: Katie J. Ryan, Charles C. White, Kruti Patel, Jishu Xu, Marta Olah, Joseph M. Replogle, Michael Frangieh, Maria Cimpean, Phoebe Winn, Allison McHenry, Belinda J. Kaskow, Gail Chan, Nicole Cuerdon, David A. Bennett, Justin D. Boyd, Jaime Imitola, Wassim Elyaman, Philip L. De Jager, Elizabeth M. Bradshaw

Institutions: Broad Institute, Brigham and Women's Hospital, Harvard University, Columbia University Irving Medical Center, Columbia University, Rush University Medical Center, The Ohio State University

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Alzheimer's Association, National Institute on Aging, National Institute of Neurological Disorders and Stroke

Awards: G2463493669, G2788870215, G4325974637, G4993122459, G5284255256, G6106434750, G7073144052, Risk Factors, Pathology, and Clinical Expressions of AD, G8725712015, G8879064777

OpenAlex ID: W2776474009

FWCI: 4.243

Cites: 79

Cited by: 159

Related to: 10