Work

Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected withHaemophilus parasuis

Year: 2017

Type: article

Abstract: A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose.The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations.Plasma TIL concentrations were determined by a validated high-performance liquid chromatography method with ultraviolet detection at 285 nm.PK parameters were calculated by using WinNonlin software.After TIL administration, the main PK parameters of TIL in healthy and H. parasuis-infected pigs were as follows: Area under the concentration-time curve, maximal drug concentration, half-life of the absorption phase, half-life of the distribution phase, and half-life of the elimination phase were 34.86 ± 9.69 vs. 28.73 ± 6.18 gㆍh/mL, 1.77 ± 0.33 vs. 1.67 ± 0.28 g/mL, 2.27 ± 0.45 vs. 2.24 ± 0.44 h, 5.35 ± 1.40 vs. 4.61 ± 0.35 h, and 43.53 ± 8.17 vs. 42.05± 9.36 h, respectively.These results of this exploratory study suggest that there were no significant differences between the PK profiles of TIL in the healthy and H. parasuis-infected pigs.

Source: Journal of Veterinary Science

DOI: 10.4142/jvs.2017.18.4.431

Authors: Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li

Institutions: Shihezi University, Xinjiang Production and Construction Corps, Tarim University

Language: English

Topic: Veterinary medicine and infectious diseases

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $300