Work

Targeting gallbladder cancer: hyaluronan sensitizes cancer cells to chemo-therapeutics.

Year: 2015

Type: article

Abstract: Gallbladder cancer is the most common biliary tract malignancy and the fifth most common gastrointestinal malignancy. Chemo-resistance is the most remarkable characteristic of gallbladder cancer. The relatively dense extracellular space in tumor is the main barrier to nanotherapeutics' anticancer efficacy. Hyaluronan (HA) was shown in our previous study to significantly improve the myxoma virus distribution via promoting the MMP-9 production, which degrades collagen IV. We demonstrated that HA increased the chemo-sensitivity of gallbladder cancer cells both in vitro and in vivo. The in vivo chemo-sensitization effect of HA could partially be due to the penetration-promoting effect of HA via degrading collagen IV.

Source: Europe PMC (PubMed Central)

Authors: Mingzhe Ma, Mingzhe Weng, Mingdi Zhang, Yiyu Qin, Wei Gong, Zhiwei Quan

Institutions: Shanghai Jiao Tong University, XinHua Hospital, Taixing People's Hospital, Yangzhou University

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W277705803

FWCI: 0.638

Cites: 9

Cited by: 7

Related to: 10