Year: 2018
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the kinetics and metabolism of caffeine in serum from patients with Parkinson disease (PD) and controls using liquid chromatography-mass spectrometry. METHODS: Levels of caffeine and its 11 metabolites in serum from 108 patients with PD and 31 age-matched healthy controls were examined by liquid chromatography-mass spectrometry. Mutations in caffeine-associated genes were screened by direct sequencing. RESULTS: gene encoding adenosine 2A receptor were detected, implying a dissociation of receptor sensitivity changes and phenotype. The profile of serum caffeine and metabolite levels was identified as a potential diagnostic biomarker by receiver operating characteristic curve analysis. CONCLUSION: Absolute lower levels of caffeine and caffeine metabolite profiles are promising diagnostic biomarkers for early PD. This is consistent with the neuroprotective effect of caffeine previously revealed by epidemiologic and experimental studies. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that decreased serum levels of caffeine and its metabolites identify patients with PD.
Source: Neurology
Institution: Juntendo University
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Generation of new mouse model for Parkinson's disease(Fostering Joint International Research), Metabolomics reveals risk factors for the development of diseases in low-birth weight infants for preemptive medicine, Pathomechanisms of Parkinson disease due to dysfunction of iPLA2G6, Examination of Caffeine Metabolism Changes and Parkinson's Disease Symptom Correlation Based on Metabolite-Related Gene Analysis, Development of anti-PD chemicals modulating autophagic activity based on lysosomal function, Development of novel cellular models for Parkinson's disease focusing on energy-homeostasis, Realization of Preemptive Medicine by elucidating the onset mechanism of diabetes attributed to mismatch between Constitution and Environment
OpenAlex ID: W2782479110