Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery
Year: 2018
Type: article
Abstract: toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy.
Source: Chemical Science
DOI: 10.1039/c8sc00206a
Institutions: Zhongnan Hospital of Wuhan University, Stanford Medicine, Stanford University, Nanjing University of Posts and Telecommunications, The Synergetic Innovation Center for Advanced Materials, Institute of Advanced Materials, Chinese Academy of Sciences, Shanghai Institute of Materia Medica
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
Funders: U.S. Department of Energy, Synergetic Innovation Center for Organic Electronics and Information Displays, National Natural Science Foundation of China, Chinese Academy of Sciences, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, National Institutes of Health, Office of Science, National Key Research and Development Program of China
Awards: 整合素αvβ3-RGD的共轭高分子近红外光声探针的制备及肿瘤成像研究, 共轭高分子光声/CT肿瘤靶向成像探针及其光热疗的应用, G3119956371, G3150690530, STANFORD MOLECULAR IMAGING RESEARCH AND TRAINING PROGRAM (SMIRTP), STANFORD MOLECULAR IMAGING RESEARCH AND TRAINING PROGRAM (SMIRTP), 基于共轭高分子的pHe敏感型NIR-II肿瘤光学成像探针及光热疗的研究, G5651753851, G7290736988, G8737213367, G8817573302, G9000346907
OpenAlex ID: W2785642747