Tratamento Medicamentoso Oral Da Hiperglicemia No Diabete Melito Tipo 2
Year: 2003
Type: article
Abstract: Diet, exercise and weight reduction are the cornerstone of type 2 diabetes mellitus (DM) treatment, since most of these patients are obese. However, the majority of the individuals is not able to achieve and mantain a satisfactory glycemic control employing only these strategies, and the prescription of complementary pharmacological treatment is often necessary. The available oral agents for type 2 diabetes treatment are divided in 5 main classes: sulfonylureas, biguanides, thiazolidinediones, alfa-glucosidase inhibitors and glinides. Phase II studies are presently in course, evaluating the safety and efficacy of new drugs. Metformin belongs to biguanides’ class, and is the drug with the best profile, since not only it lowers glycemia, but it also reduces appetite and weight, and , most of all, it is the only drug that diminishes mortality rates. Data regarding indications, mechanisms of action and adverse effects of the above mentioned drugs are describe in the present review.
Source: Americanae (AECID Library)
Language: Portuguese
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2787464239