Antibacterial triterpenoids from the leaves of Ilex hainanensis Merr.
Year: 2018
Type: article
Abstract: One new triterpenoid (1) and seven known analogues (2–8) were isolated from the leaves of Ilex hainanensis Merr.. Their structures were established by analysis of their MS, 1D and 2D NMR spectroscopic data and comparison with those in the literature. The antibacterial activity of compounds 1–8 were evaluated by determination of minimum inhibitory concentration using twofold microdilution broth method against Streptococcus mutans ATCC 25175 (Gram-positive) and Fusobacterium nucleatum ATCC 10953 (Gram-negative). Compounds 3 and 5 showed significant antibacterial activity against S. mutans in concentration of 9.7 μg/mL, while showed little antibacterial activity against F. nucleatum. On the contrary, the inhibitory activity of compounds 1, 2 and 6 against F. nucleatum were higher than them against S. mutans.
Source: Natural Product Research
Authors: Wen-Wen Zhao, Ke Zan, Jing-Yue Wu, Wei Gao, Jie Yang, Yin-Ying Ba, Xia Wu, Xiao-Qing Chen
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Awards: G1164621987, G4809825431, G8246942070
OpenAlex ID: W2793673436