Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice
Year: 2018
Type: preprint
Abstract: To examine the functional contribution of Inflammatory Bowel Disease (IBD) microbes to immune homeostasis and colitis, we colonized unchallenged and colitis-susceptible germ-free mice with over twenty human intestinal microbiotas from healthy and IBD donors. Compared to healthy microbiotas, IBD microbiotas led to expanded RORγt + Th17 cells and reduced RORγt + Treg in the gut of unchallenged gnotobiotic mice and increased disease severity in colitis-susceptible mice. The proportions of RORγt + Th17 and RORγt + Treg induced by each microbiota were highly predictive of the human disease status and strongly correlated with disease severity in colitis-susceptible mice colonized with the same human microbiotas. The transmittable functional potential of IBD microbes suggests a mechanism for a microbial contribution to IBD pathogenesis and a potential route for its treatment and prevention.
DOI: 10.1101/276774
Authors: Graham J. Britton, Eduardo J. Contijoch, Ilaria Mogno, Olivia H. Vennaro, Sean R. Llewellyn, Ruby Ng, Zhihua Li, Arthur Mortha, Miriam Merad, Anuk Das, Dirk Gevers, Dermot P.B. McGovern, Namita Singh, Jonathan Braun, Jonathan P. Jacobs, Jose C. Clemente, Ari Grinspan, Bruce E. Sands, Jean-Frederic Colombel, Marla C. Dubinsky, Jeremiah J. Faith
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2796200035