Work

Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives

Year: 2018

Type: article

Abstract: Benzimidazole derivatives 1–20 were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 ± 1.20 and 473.51 ± 2.17 when compared with standard rutin (IC50 value 295.09 ± 1.04 µM) and for antioxidant potential ranging between 22.42 ± 0.26 and 82.30 ± 1.33 when compare with standard Propyl gallate (IC50 value 29.20 ± 1.25). Compound 2, 6, 10 and 19 showed potent antioxidant and antiglycation inhibitory potentials. Compounds 7, 11, 13, 15 and 20 showed moderate antiglycating potential with IC50 values 473.51 ± 2.17, 325.20 ± 1.70, 440.0 ± 3.60, 370.60 ± 2.80 and 415.20 ± 3.20 μM, and these compounds also showed excellent antioxidant potential with IC50 values 73.51 ± 1.17, 45.63 ± 0.92, 82.30 ± 1.33, 75.41 ± 1.51, 40.60 ± 0.80 and 64.92 ± 1.41 μM respectively. The remaining compounds 1, 3, 4, 5, 8, 9, 12, 14, 16, 17and 18 were found inactive.

Source: Journal of King Saud University - Science

DOI: 10.1016/j.jksus.2018.04.003

Authors: Muhammad Taha, Ashik Mosaddik, Fazal Rahim, Sajjad Ali, Mohamed Ibrahim, Noor Barak Almandil

Institutions: Imam Abdulrahman Bin Faisal University, Hazara University, Karakoram International University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,600