Work

Cover Picture: Catalyst‐Enabled Site‐Divergent Stereoselective Michael Reactions: Overriding Intrinsic Reactivity of Enynyl Carbonyl Acceptors (Angew. Chem. Int. Ed. 17/2018)

Year: 2018

Type: article

Abstract: Two distinct catalysts … … (+)-cinchonidine-derived thiourea (shown as an archerfish) and L-isoleucine-derived triaminoiminophosphorane (arowana), were used in a site-divergent, diastereo- and enantioselective Michael addition of prochiral enolates to enynyl N-acyl pyrazoles (branch). As described by T. Ooi and co-workers in their Communication on page 4732 ff., a judicious choice in catalyst can lead to either the 1,4- or 1,6-addition product.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201802880

Authors: Daisuke Uraguchi, Ryo Shibazaki, Naoya Tanaka, Kohei Yamada, Ken Yoshioka, Takashi Ooi

Institutions: Institute of Transformative Bio-Molecules, Nagoya University, Japan Science and Technology Agency

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2799366117

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