Work

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Year: 2018

Type: article

Abstract: α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.

Source: Tissue Barriers

DOI: 10.1080/21688370.2018.1463896

Authors: Sergio E. Chiarella, Erik E. Rabin, Lorena A. Ostilla, Annette S. Flozak, Cara J. Gottardi

Institution: Northwestern University

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid