Year: 2018
Type: review
Abstract: The global incidence of inflammatory bowel disease (IBD), a group of chronic gastrointestinal disorders, has been rising. The preponderance of evidence demonstrates that oxidative stress (OS) performs a critical function in the onset of IBD and the manner of its development. The purpose of this review is to outline the generation of reactive oxygen species and antioxidant defense mechanisms in the gastrointestinal tract and the role played by OS in marking the onset and development of IBD. Furthermore, the review demonstrates the various ways through which OS is related to genetic susceptibility and the mucosal immune response. The experimental results suggest that certain therapeutic regimens for IBD could have a favorable impact by scavenging free radicals, reducing cytokine and prooxidative enzyme concentrations, and improving the antioxidative capabilities of cells. However, antioxidative activity characterized by a high level of specificity may be fundamental for the development of clinical therapies and for relapsing IBD patients. Therefore, additional research is required to clarify the ways through which OS is related to the pathogenesis and progression of IBD.
Source: BioMed Research International
DOI: 10.1155/2018/1290179
Authors: Guiping Guan, Shile Lan
Institution: Hunan Agricultural University
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Funders: U.S. Department of Veterans Affairs, Education Department of Hunan Province, National Natural Science Foundation of China, Hunan Provincial Science and Technology Department, Nanchang University, Hunan Provincial Innovation Foundation for Postgraduate, State Key Laboratory of Food Science and Technology, State Key Laboratory of Food Science and Technology, Nanchang University
Awards: G1159677433, G1217802100, G1270252632, G1545329357, G1600750316, G1958404780, G2912613590, G3091585208, G3174475349, G3393679317, G3773035082, G3808813408, G4091788382, G4209430888, G4250931971, G4453597498, G460007632, G4987487260, G5101126840, G5175134995, G5704884474, G6009611716, G6315598808, G6320937824, G6590693904, G6672959711, G6695983378, G7032783165, G7702328347, G7754582042, G8427024679
OpenAlex ID: W2801650643