Year: 2018
Type: article
Abstract: Fructose is one of the most common dietary carbohydrates, accounting for ~5–15% of daily calorie intake. Because of its lower glycemic index compared to glucose, fructose has been utilized for a long time as a food sweetener for serving people with diabetics, children, and elderly 1 . In the last decade, strong attention has been drawn to focus on the influence of fructose consumption on many diseases, including tumorigenesis, because of its large intake world widely. Biologically, following the intestinal ingestion, most of the food-origin fructose is converted into glycogen and fat in liver tissue, while the rest enters bloodstream for the direct metabolism in other organs. Unlike glucose, of which concentration is tightly controlled through endocrine signaling, the level of serum fructose fluctuates from micromole to millimole per liter, largely depending on the amount of intake 2 . Data on epidemiological survey have demonstrated that conditions including obesity, diabetes, as well as heart and kidney diseases are correlated with long-term high-fructose intake, which is commonly seen in various modern diets 2 . (Fig. 1 ) Fig. 1: Fructose promotes lung adenocarcinoma cell survival and metastasis through GLUT5. LUAD cells utilize both glucose and fructose as nutrients for energetic and biosynthetic purposes. Especially, when glucose is scarce, fructose may function as a crucial alternative. Fructose, ingested through GLUT5, could efficiently enhance cancer cell proliferation, migration, invasion, and tumorigenicity. Compared to glucose, fructose metabolism facilitates intracellular FFA accumulation and ATP production while decreases NADPH and lactate in LUAD cells. The green arrow indicates that fructose produces less metabolites than glucose under the same concentration, while the red arrow indicates the opposite trend. FFA free fatty acid, 2,5-Anhydro-D-mannitol fructose analog with high affinity for GLUT5 Full size image
Source: Cell Death and Disease
Institutions: Quzhou City People's Hospital, China Medical University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,990
Award: G3385766220
OpenAlex ID: W2802048403