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A Comparative Study of Cell Block With Conventional Smear Cytology in Diagnosing Serous Effusions- a Descriptive Study

Year: 2018
Type: article
Study design: Observational Study
Abstract: BACKGROUNDConventional cytology is the branch of pathology dealing in diagnosis of various fluids.But screening of remaining residue, which is not processed may be of paramount importance for diagnosis.The residual material may be evaluated by cell block preparation.Cell block study along with conventional smear cytology may improve the sensitivity of diagnosis.It is widely accepted that cellblock technique increases the cellular yield and improves diagnostic accuracy.The ability to obtain numerous tissue sections allows for multiple immunostains and other studies to be performed akin to paraffin sections produced in histopathology.Aims and objectives-The present study is undertaken to assess diagnostic efficacy of cell block preparation (CB) by combined approach of conventional smear (CS) cytology and cell block preparation in serous effusions. MATERIALS AND METHODSIn this Descriptive study, material for both conventional cytology and cell blocks were collected simultaneously as per convenience.Total 98 samples were evaluated.Grading of cellularity, morphological preservation, architectural preservation and presence of background staining were compared. RESULTSOf the total 98 undergoing conventional cytological analyses, 74 (75.5 %) were reported as benign, 19 (19.3%) as malignant and 05 (5.10%) as suspicious of malignancy.With the cell block method, the results were 76 (77.55%) benign and 22 (22.44%)malignant. CONCLUSIONOur study confirmed that the cell block method increases the diagnostic yield.Direct fluid smears and cell blocks complement each other, and our results indicate that both are needed in the diagnostic work-up of patients.
DOI: 10.14260/jemds/2018/175
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W2802153265
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Cites: 9
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Related to: 10