Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder
Year: 2018
Type: article
Study design: Case Report
Abstract: We herein report the case of a 76-year old man with aquaporin-4-Immunoglobulin-G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD), in whom transient interstitial pulmonary lesions developed at the early stage of the disease. Chest X-ray showed multiple infiltrative shadows in both upper lung fields, and computed tomography revealed abnormal shadows distributed randomly in the lungs. Surgical lung biopsy showed features of unclassifiable interstitial pneumonia, characterized by various types of air-space organization, which resulted in obscure lung structure. This is the first report to describe the pathological findings of interstitial pneumonia, which may represent a rare extra-central nervous system complication of NMOSD.
Source: Internal Medicine
Institutions: National Hospital Organization, Tokyo Metropolitan Police Hospital, National Hospital Organization Saitama Hospital, Itabashi Chuo Medical Center, National Hospital Organization Nishisaitama-Chuo National Hospital, Tohoku University, National Hospital Organization Yonezawa Hospital, Fukushima Medical University, Southern TOHOKU Research Institute for Neuroscience, Saitama Prefecture, Saitama Cardiovascular and Respiratory Center
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2804366133