Work

Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector

Year: 2018

Type: article

Abstract: Accumulation of amyloid β (Aβ40 and Aβ42) in the brain is a characteristic of Alzheimer's disease (AD). Because neprilysin (NEP) is a major Aβ-degrading enzyme, NEP delivery in the brain is a promising gene therapy for AD. Borna disease virus (BoDV) vector enables long-term transduction of foreign genes in the central nerve system. Here, we evaluated the proteolytic ability of NEP transduced by the BoDV vector and found that the amounts of Aβ40 and Aβ42 significantly decreased, which suggests that NEP expressed from the BoDV vector is functional to degrade Aβ.

Source: Microbiology and Immunology

DOI: 10.1111/1348-0421.12602

Authors: Madoka Sakai, Sakiho Ueda, Takuji Daito, Megumi Asada‐Utsugi, Yumiko Komatsu, Ayae Kinoshita, Takakuni Maki, Akira Kuzuya, Ryosuke Takahashi, Akiko Makino, Keizo Tomonaga

Institutions: Kyoto University, Hokkaido University, Hokkaido University International Institute for Zoonosis Control

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Japan Agency for Medical Research and Development, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science

Awards: G163335109, G1649966974, G2241728962, Generation of episomal RNA viral vector for stem cell gene therapy, G6104434301, G6802760042, Study on DNA damage responses for regulation of intranuclear RNA viruses, G7257929133, G8728950419, G8769996592, G8873078592

OpenAlex ID: W2804565607

FWCI: 0.782

Cites: 50

Cited by: 12

Related to: 10