Soluble Macrophage Mannose Receptor (sCD206/sMR) as a Biomarker in Human Immunodeficiency Virus Infection
Year: 2018
Type: article
Study design: Observational Study
Abstract: Macrophages play important roles during human immunodeficiency virus (HIV) infection, reflected by changes in macrophage-activation biomarker soluble CD163 (sCD163). Here, we present data on the novel macrophage-activation biomarker soluble mannose receptor/CD206 (sCD206) in HIV infection. We investigated sCD206 blood levels at baseline and follow-up with/without antiretroviral therapy (ART), in 212 patients with HIV type 1 (HIV-1), HIV type 2 (HIV-2), or dual infection. At baseline, there was no difference in sCD206 level between HIV types, and sCD206 was unchanged at follow-up without ART. However, in contrast to sCD163, sCD206 levels decreased significantly for both HIV-1 and HIV-2, but not for HIV-1/2 patients, during ART. Further investigations are needed to establish sCD206 as a biomarker in HIV infection.
Authors: Morten N Andersen, Bo L Hønge, Sanne Jespersen, Candida Medina, David da Silva Té, Alex Laursen, Christian Wejse, Christian Erikstrup, Holger J Møller, Bissau HIV Cohort Study Group, Amabelia Rodrigues, David da Silva Té, Zacarias da Silva, Candida Medina, Ines Oliviera-Souto, Lars Østergaard, Alex Lund Laursen, Peter Aaby, Anders Fomsgaard, Christian Erikstrup, Bo Langhoff Hønge, Christian Wejse, Sanne Jesperse
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2804699644