Year: 2018
Type: article
Abstract: The survey analyzes the literature data on biosynthesis, reception, degradation, and physiological effects of the melanocortin family regulatory peptides. Information on the interaction of melanocortins with neurotransmitters of the brain, as well as their effect on the functional state of the organism regulatory systems, is presented. The neurotropic and immunotropic effects of peptides of the melanocortin family are reflected, as well as their effect on separate organs and systems, in particular: liver, cardiovascular system and hemostasis. The main pharmacological effects and mechanisms of action of the "Semax" drug created on the basis of the ACTH synthetic fragment are described. The data presented in the survey reflect the significant physiological activity and polyfunctionality of regulatory peptides of the melanocortin family, substantiated by a considerable number of studies, as well as the prospects of creating new pharmacological melanocortin-based preparations.
Source: Человек и его здоровье
Authors: С. А. Додонова, А. Е. Белых, И. И. Бобынцев
Institution: Kursk State Medical University
Language: Russian
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2804777567