Work

Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles

Year: 2018

Type: article

Abstract: The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.

Source: ACS Sustainable Chemistry & Engineering

DOI: 10.1021/acssuschemeng.8b01652

Authors: Mika H. Sipponen, Heiko Lange, Mariko Ago, Claudia Crestini

Institutions: University of Rome Tor Vergata, Aalto University

Language: English

Topic: Lignin and Wood Chemistry

Subfield: Process Chemistry and Technology

Field: Chemical Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500