Is there a role for combined use of Gabapentin and Pregabalin in pain control? Too good to be true?
Year: 2018
Type: other
Abstract: Gabapentin (Neurontin) and Pregabalin (Lyrica) are first and second-generation α2delta ligands, respectively, and are both approved for use as adjunctive therapy in pain control. Their mechanism of action is not yet fully understood, but research has demonstrated promising results. Despite their similarities, they have been used in combination in both clinical and research settings, and have been noted to have a synergistic effect in pain control without concern for clinically significant pharmacokinetic interactions. This combined approach can be valuable in pain management by reducing the dose of individual agent, its side effects, and to enhance therapeutic response compared to a single agent in resistant cases.
Institution: Baycrest Academy for Research and Education
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W2805605813