Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy
Year: 2018
Type: review
Abstract: Both disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) cause microvascular thrombosis associated with thrombocytopenia, bleeding tendency and organ failure. The frequency of DIC is higher than that of thrombotic thrombocytopenic purpura (TTP). Many patients with TMA are diagnosed with DIC, but only about 15% of DIC patients are diagnosed with TMA. Hyperfibrinolysis is observed in most patients with DIC, and microangiopathic hemolytic anemia is observed in most patients with TMA. Markedly decreased ADAMTS13 activity, the presence of Shiga-toxin-producing Escherichia coli (STEC) and abnormality of the complement system are useful for the diagnosis of TTP, STEC-hemolytic uremic syndrome (HUS)and atypical HUS, respectively. However, there are no specific biomarkers for the diagnosis of DIC. Although DIC and TMA are similar appearances, all coagulation, fibrinolysis and platelet systems are activated in DIC, and only platelets are markedly activated in TMA.
Source: Thrombosis Journal
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,090
Awards: Behavioral Big Data Analysis Reveals a Pivotal Role of ICU Staff in Promoting Inter- and Intra-Staff Communication., Basic construction of WT1-targetting CAR-T therapy for acute myeloid leukemia, Involvement of ADAMTS 13 in liver failure after hepatectomy and establishment of novel liver failure treatment strategy
OpenAlex ID: W2805630869