SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity
Year: 2018
Type: article
Abstract: Muscle satellite cells are the primary source of stem cells for postnatal skeletal muscle growth and regeneration. Understanding genetic control of satellite cell formation, maintenance, and acquisition of their stem cell properties is on-going, and we have identified SOXF (SOX7, SOX17, SOX18) transcriptional factors as being induced during satellite cell specification. We demonstrate that SOXF factors regulate satellite cell quiescence, self-renewal and differentiation. Moreover, ablation of Sox17 in the muscle lineage impairs postnatal muscle growth and regeneration. We further determine that activities of SOX7, SOX17 and SOX18 overlap during muscle regeneration, with SOXF transcriptional activity requisite. Finally, we show that SOXF factors also control satellite cell expansion and renewal by directly inhibiting the output of β-catenin activity, including inhibition of Ccnd1 and Axin2. Together, our findings identify a key regulatory function of SoxF genes in muscle stem cells via direct transcriptional control and interaction with canonical Wnt/β-catenin signaling.
Source: eLife
DOI: 10.7554/elife.26039
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,887
Funders: Association Française contre les Myopathies, FSH Society, Muscular Dystrophy UK, European Commission, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Centro Nacional de Investigaciones Cardiovasculares, Horizon 2020 Framework Programme, Medical Research Council, Institut de Myologie
Awards: G1244451820, G1326681891, G1362745698, Role de la sénescence du tissu adipeux dans les co-morbidités des pathologies métaboliques, G2409817632, Histone demethylases in epigenetic control of muscle development and physiology, G2846574407, Muscle stem cell quiescence and heterogeneity, G351535799, G4473915316, In vivo analysis of muscle stem cells vascular niche, G4617827065, G5054008497, Bone-Muscle cross talks in musculoskeletal regeneration, G5357539692, G6263255493, Control of skeletal muscle mass by Bone Morphogenetic proteins, G7060035805, G7845610343, Adult skeletal muscle stem cell regulation by Bone morphogenetic protein signaling, Stem Cells in Regenerative Biology and Medicine, Understanding and Ameliorating Pathogenesis in FSHD
OpenAlex ID: W2805876407