Work

Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence

Year: 2018

Type: article

Abstract: Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.

Source: Aging and Disease

DOI: 10.14336/ad.2017.0628

Authors: Zheng Zhang, Linlei Zhang, Yuchuan Ding, Zhao Han, Xunming Ji

Institutions: Capital Medical University, Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Xuan Wu Hospital of the Capital Medical University, Wayne State University

Language: English

Topic: Thermal Regulation in Medicine

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000