Work

A pilot study evaluating the potential of diffusional kurtosis imaging applied to alzheimer's disease

Year: 2017

Type: article

Abstract: Aim: To estimate the potential of Diffusional Kurtosis Imaging (DKI), a method sensitive to microstructural damage for detecting the effects of Alzheimer's Disease (AD) compared to those of aging, in prodromal AD (PDAD). Materials and methods:Young subjects (N=4, age=25±3), old subjects (N=7, age=65±8) and AD patients (N=5, age=74±7) were recruited.Mean kurtosis (K app ) in white matter (WM), grey matter (GM) were measured in the cerebellum, frontal lobe and temporal lobe, and differences were assessed with the non-parametric Kruskal-Wallis test.Results: There was no age difference between PDAD patients and older subjects (P>0.05).Mini-Mental State Examination (MMSE) scores of the patients were lower (P<0.02)and comparatively in PDAD:-Kurtosis K app was decreased in the temporal lobe WM only (P<0.05).There was a significant age difference in older subjects compared to young subjects, (P<0.01) and comparatively in aging:-K app was decreased in the frontal lobe WM only (P<0.03).Conclusion: K app decreases were found in the WM of the temporal lobe in PDAD and in the WM of the frontal lobe in aging, in accordance with previous studies.As PDAD microstructural and metabolic disturbances occur essentially in the temporal lobes where K app changes were also found, DKI might be a useful non-invasive method for the detection of Alzheimer's disease in the prodromal stage.

Source: Nuclear Medicine and Biomedical Imaging

DOI: 10.15761/nmbi.1000128

Authors: Nicolas R, Saint-Aubert L, Gros-Dagnac H, Franceries X, Pariente J

Institutions: Université Toulouse III - Paul Sabatier, Inserm, Université de Toulouse

Language: English

Topic: Advanced Neuroimaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2807046567