Work

Controlled Release of RNAi Molecules by Tunable Supramolecular Hydrogel Carriers

Year: 2018

Type: article

Abstract: Local, sustained release and presentation of RNAi therapeutics can be achieved with hydrogel delivery systems. Here we show the development of a supramolecular hydrogel into a local RNAi delivery system. By careful material design, two simple but effective strategies are introduced to obtain controlled release of two classes of RNAi therapeutics, that is, microRNA and antimiR. It was shown that the release of microRNA could be regulated using cholesterol-modification for interaction with the supramolecular hydrogel. Non-modified antimiR release could be controlled via supramolecular introduction of positively charged additive molecules into the supramolecular hydrogel. In this way, either the cholesterol-modification on the drug or the charge introduction into the hydrogel provides handles for controlled RNAi therapy.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.201800582

Authors: Maarten H. Bakker, Eva van Rooij, Patricia Y. W. Dankers

Institutions: Eindhoven University of Technology, University Medical Center Utrecht

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Hartstichting, Ministerie van Onderwijs, Cultuur en Wetenschap, FP7 Ideas: European Research Council