Year: 2018
Type: article
Study design: Observational Study
Abstract: Interleukin-4 (IL-4) is a potent growth and differentiation factor for B cells which play a vital role in the pathogenesis of myasthenia gravis (MG). IL-4 exerts its function by binding to three types of IL-4 receptor (IL-4R) complexes. IL-4Rα is the key component of the IL-4R complex. We hypothesize that polymorphism of IL-4Rα gene may be associated with the susceptibility and severity of MG. A Chinese cohort of 480 MG patients and 487 healthy controls were recruited. Polymorphisms of IL-4Rα gene were determined with SNPscan™ methods and compared between MG and control groups, as well as among MG subgroups. Rs2107356 and rs1805010 were found to be associated with adult thymoma associated MG, and rs1801275 was found to be associated with adult non-thymoma AChR-Ab positive MG. We did not found association between IL-4Rα polymorphism and the severity of MG. Genetic variations of IL-4Rα were found associated with the susceptibility of MG in Chinese Han population.
Source: Frontiers in Neurology
Authors: Ping Jiang, Yao-Xian Yue, Yu Hong, Yanchen Xie, Xiang Gao, Chuan-Kai Gu, Hong-Jun Hao, Yue Qin, Xiao-Jun Ding, Min Song, Hai-Feng Li, Xu Zhang
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Shandong University, Qilu Hospital of Shandong University, National Natural Science Foundation of China, Capital Medical University, Natural Science Foundation of Shandong Province, Qingdao University, Key Technology Research and Development Program of Shandong, Beijing Municipal Natural Science Foundation, Beijing Friendship Hospital, Capital Medical University
OpenAlex ID: W2807951925