Year: 2018
Type: article
Study design: Observational Study
Abstract: Background: Diagnosis of malignant pleural mesothelioma (MPM) remains a challenge, especially when resources in pathology are limited.The study aimed to evaluate cost-effective tumor markers to predict the probability of MPM in plasma samples in order to accelerate the diagnostic workup of the tissue of potential cases.Methods: We conducted a case-control study stratified by gender, which included 75 incident cases with MPM from three Mexican hospitals and 240 controls frequency-matched by age and year of blood drawing.Plasma samples were obtained to determine mesothelin, calretinin, and thrombomodulin using enzyme-linked immunosorbent assays (ELISAs).We estimated the performance of the markers based on the area under the curve (AUC) and predicted the probability of an MPM diagnosis of a potential case based on the marker concentrations.Results: Mesothelin and calretinin, but not thrombomodulin were significant predictors of a diagnosis of MPM with AUCs of 0.90 (95% CI: 0.85-0.95),0.88 (95% CI: 0.82-0.94),and 0.51 (95% CI: 0.41-0.61) in males, respectively.For MPM diagnosis in men we estimated a true positive rate of 0.79 and a false positive rate of 0.11 for mesothelin.The corresponding figures for calretinin were 0.81 and 0.18, and for both markers combined 0.84 and 0.11, respectively.Conclusions: We developed prediction models based on plasma concentrations of mesothelin and calretinin to estimate the probability of an MPM diagnosis.Both markers showed a good performance and could be used to accelerate the diagnostic workup of tissue samples in Mexico.
DOI: 10.7150/ijms.23939
Authors: Guadalupe Aguilar-Madrid, Beate Pesch, Emma S Calderón-Aranda, Katarzyna Burek, Carmina Jiménez-Ramírez, Cuauhtémoc Arturo Juárez-Pérez, María Dolores Ochoa-Vázquez, Luis Torre-Bouscoulet, Leonor Concepción Acosta-Saavedra, Isabel Sada-Ovalle, Jorge García-Figueroa, Isabel Alvarado-Cabrero, Patricia Castillo-González, Alejandra Renata Báez-Saldaña, José Rogelio Pérez-Padilla, Juvencio Osnaya-Juárez, Rosa María Rivera-Rosales, Eric Marco García-Bazán, Yolanda Lizbeth Bautista-Aragón, Elimelec Lazcano-Hernandez, Daniel Alejandro Munguía-Canales, Luis Marcelo Argote-Greene, Dirk Taeger, Daniel Gilbert Weber, Swaantje Casjens, Irina Raiko, Thomas Brüning, Georg Johnen
Institutions: Mexican Social Security Institute, Institute for Prevention and Occupational Medicine, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Instituto Nacional de Enfermedades Respiratorias, University Hospitals of Cleveland, Case Western Reserve University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W2808074008