Year: 2016
Type: article
Abstract: Journal of Proteomics and GenomicsVillin is one of the major cytoskeleton proteins that bind to actin.It is localized to some specific tissues like the microvilli of intestine and kidney [1].Some of the cell types present in the unorganized brush border in the pancreatic and bile duct also have villin, although at very low concentration.These cells help in the absorption process exactly similar to functional microvilli of intestine and kidney.Villin is also expressed in intestinal cells of the embryo [2].Villin belongs to a large class of actin regulating proteins.Regulation of the actin filaments is performed by actin binding proteins.These proteins assist the sequestration of actin monomers, severing and cross-linking of filaments, and cover their ends [3].In humans, the villin is encoded by two mRNAs of dissimilar lengths and surprisingly, the coding region of their cDNAs shows no difference.
Source: Journal of Proteomics & Genomics
Authors: Sabharwal NS, Runthala A
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2808092192