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The Role of Oxidative Stress and Inflammation in Acute Oxalate Nephropathy Associated With Ethylene Glycol Intoxication

Year: 2018

Type: article

Abstract: Calcium oxalate crystal (CaOx) deposition within the renal parenchyma is well described as a cause of both acute kidney injury and chronic kidney disease. Animal and cell line studies have previously demonstrated that this injury is modulated by oxidative stress−induced danger-associated molecular patterns following CaOx deposition within the interstitium1,2. It has been postulated that these oxidative stress-induced danger-associated molecular patterns may participate in the pathogenesis of acute kidney injury and chronic kidney disease in humans, leading to the recruitment of an inflammatory response characterized by an increased infiltration of monocytes and macrophages.

Source: Kidney International Reports

DOI: 10.1016/j.ekir.2018.05.005