Work

Hepatic stellate cells (HSCs) activating HSF1-mediated COMP secretion promote liver metastasis of pancreatic cancer through CD36/AKT/FOXM1 signaling

Year: 2018

Type: article

Abstract: Introduction: Previous studies demonstrated that primary pancreatic cancer cells can release circulating factors or exosomes into the liver to form premetastatic niches. HSCs are important in forming premetastatic niches because they can transdifferentiate into the tumor-associated myofibroblasts, and then promote metastasis and growth of pancreatic cancer cells. The transcriptional regulator heat shock factor 1 (HSF1) is frequently activated in tumor stroma, and Cartilage oligomeric matrix protein (COMP) is a 524 kDa soluble glycoprotein particularly expressed in fibrotic conditions.

Source: Annals of Oncology

DOI: 10.1093/annonc/mdy151.034