Selective internal radiation therapy (SIRT) with yttrium-90 microspheres and peri-procedural FOLFIRI/irinotecan in pre-treated colorectal liver metastases patients: An analysis of outcomes from a UK Cancer Centre between 2009 and 2017
Year: 2018
Type: article
Study design: Observational Study
Abstract: Introduction: Selective Internal Radiation Therapy (SIRT) involves hepatic intra-arterial infusion of β-particle emitting Yttrium-90 labelled microspheres. SIRT increases first line response rates (RR) and hepatic progression free survival (hPFS) in liver predominant metastatic colorectal cancer (mCRC) patients treated with oxaliplatin/5FU/folinic acid (FOLFOX). SIRT is often used in pre-treated mCRC patients with peri-procedural FOLFOX to achieve radio-sensitization and control extra-hepatic disease.
Source: Annals of Oncology
Authors: G. Wilson, D. Bentley, S. Mullamitha, M. Braun, M. Nasralla, J. Bell, D. Mullan, J. Hasan, M. Saunders, F. Marti, C. McBain, N. Alam, H. Laasch, P. Najran, T. Westwood, S. Jeans, J. Tipping, P. Manoharan, J. Lawrance
Institutions: The Christie NHS Foundation Trust, The Christie Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,080
OpenAlex ID: W2809057232