Year: 2018
Type: review
Abstract: Recurrent laryngeal nerve (RLN) injury has considerable clinical implications, including voice and swallowing dysfunction, which may considerably impair the patient’s quality of life. Recovery of vocal fold movement is an essential novel treatment option for RLN injury. The potential of gene therapy for addressing this issue is highly promising. The target sites for RLN gene therapy are the central nervous system, nerve fibers, laryngeal muscles, and vocal cord mucosa. Gene transduction has been reported in each site using viral or non-viral methods. The major issues ensuing after RLN injury are loss of motoneurons in the nucleus ambiguus, degeneration and poor regeneration of nerve fibers and motor end plates, and laryngeal muscle atrophy. Gene therapy using neurotrophic factors has been assessed for most of these issues, and its efficacy has been reported. Another important matter for functional vocal fold movement recovery is misdirected regeneration, in which the wrong neurons may innervate other laryngeal muscles, where even if innervation is reestablished, proper motor function is not restored. Novel strategies involving gene therapy bear promise for overcoming this issue and further investigations are underway.
Source: Genes
DOI: 10.3390/genes9070316
Institution: National Defense Medical College
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,137
Awards: Development of oncolytic sendai virus therapy for head and neck cancer for clinical application, The development of a novel minimally invasive strategy targeting sentinel lymph node for head and neck cancer., Development toward clinical application of functional preservation therapy for control of cervical lymph node metastasis in head and neck cancer., G664195916, G7974965222, New treatment strategy to prevent misdirection in recurrent laryngeal nerve regeneration., The therapeutic efffect of Oncolytic recombinant Sendai Virus against refractory head and neck cancer., The development of new treatments for peripheral nerve misderected regeneration, G8589572369
OpenAlex ID: W2809324486