Work

Blackberry and Blueberry Anthocyanin Supplementation Counteract High‐Fat‐Diet‐Induced Obesity by Alleviating Oxidative Stress and Inflammation and Accelerating Energy Expenditure

Year: 2018

Type: article

Abstract: Many studies indicate that an anthocyanin‐rich diet has beneficial effects preventing metabolic disease. In the present study, the molecular mechanism underlying the antiobesity effect of consuming blackberry anthocyanins (BLA) and blueberry anthocyanins (BBA) was investigated in high‐fat‐diet‐ (HFD‐) fed C57BL/6 mice. Sixty mice were administered a low‐fat diet (LFD), a HFD, or a HFD plus orlistat, and BLA or BBA in their daily food for 12 weeks. As a result, the consumption of BLA and BBA inhibited body weight gain by 40.5% and 55.4%, respectively, in HFD‐fed mice. The BLA and BBA treatments markedly reduced serum and hepatic lipid levels and significantly increased hepatic superoxide dismutase and glutathione peroxidase activities. In addition, the treatments effectively increased fecal acetate and butyrate levels and significantly attenuated expression of tumor necrosis factor TNF‐α, interleukin‐6, and nuclear factor‐kappaB genes. Moreover, gas chromatography time‐of‐flight mass spectroscopy results suggested that BLA and BBA significantly affected the hepatic lipid and glucose metabolic pathways, including glycerophospholipid metabolism, glutathione metabolism, and the insulin‐signaling pathway. Therefore, BLA and BBA ameliorated diet‐induced obesity by alleviating oxidative stress and inflammation and accelerating energy expenditure.

Source: Oxidative Medicine and Cellular Longevity

DOI: 10.1155/2018/4051232

Authors: Tao Wu, Yufang Gao, Xueqi Guo, Min Zhang, Lingxiao Gong

Institutions: Tianjin University of Science and Technology, Beijing Technology and Business University, Beijing Advanced Innovation Center for Food Nutrition and Human Health

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Estimated APC paid: $2,680