Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention
Year: 2018
Type: article
Study design: Observational Study
Abstract: Objective: Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention.Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI).Methods: In 53 patients who underwent PCI were enrolled.Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization.Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization.CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline.Results: CIN occurred in four patients (7.5%).Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P< 0.05).Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN.Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN.There were no significant markers of CIN on multi-variate analysis.Conclusion: In this study, the occurrence of CIN after PCI was 7.5%.Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.
Source: Soonchunhyang Medical Science
DOI: 10.15746/sms.18.003
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2809933448